
Published by Oxford University Press on behalf of the International Epidemiological Association. Mendelian randomization meta-epidemiology reproducibility. Journals and researchers should consider using the STROBE-MR guidelines to improve reporting quality.

The quality of reporting of two-sample Mendelian randomization studies in our sample was generally poor. We did not find evidence of a change in reporting quality over time or a difference in reporting quality between studies that used MR-Base and a random sample of MR studies that did not use this platform. Many items required for evaluating the validity of key assumptions made in MR were poorly reported: only 44% of studies provided sufficient details for assessing if the genetic variant associates with the exposure ('relevance' assumption), 31% for assessing if there are any variant-outcome confounders ('independence' assumption), 89% for the assessing if the variant causes the outcome independently of the exposure ('exclusion restriction' assumption) and 32% for assumptions of falsification tests. Reporting quality was generally poor across studies, with a mean of 53% (SD = 14%) of items reported in each study. There have been a few I’ve played over the years, and even a few I enjoyed like Starbase Startopia. In the primary analysis, 87 studies were included. I always wanted to play a really good base management and/or building game with a focus on space stations. Study screening and data extraction were performed by at least two independent reviewers. We then searched Web of Science Core Collection, PsycInfo, MEDLINE, EMBASE and Google Scholar citations of the MR-Base descriptor paper to identify published MR studies that used MR-Base for any component of the MR analysis. We created a bespoke reporting checklist to evaluate reporting quality of 2SMR studies.

We aimed to assess the reporting quality of studies that used MR-Base, one of the most popular platforms for implementing 2SMR analysis. However, the quality of methodological reporting of 2SMR studies is currently unclear. Clear reporting of methods employed in such studies is important for evaluating their underlying quality. Also included is a Custom Game mode for the more experienced player who want to build their own campaign with their own conditions and quests.Two-sample Mendelian randomization (2SMR) is an increasingly popular epidemiological method that uses genetic variants as instruments for making causal inferences. Keep space pirates at bay with the best military expertise EGU can provide!īuild your own "Solution" expedition, listen to the various tales the crew have in store for you and explore undiscovered systems.
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